Fever is usually a sign that the immune system is working extremely hard. During an infection, the immune system raises the body’s temperature by secreting certain chemicals that increase the production and activity of immune cells. This slows down an invader’s ability to reproduce, resisting its attack. Indiscriminately lowering a fever may help make it more difficult for the immune system to overcome the infection. Fever medications have side effects including paracetamol, widely used clinically can lead to side effects like death of liver and kidney cells, neurotoxicity, and brain damage. Such side effects should not be overlooked as they associate with many death cases.